Erratum: Kinetochore-microtube attachments in cancer therapy
نویسندگان
چکیده
منابع مشابه
Erratum: Kinetochore-microtube attachments in cancer therapy
[This corrects the article on p. 902 in vol. 2, PMID: 26697517.].
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The process of cell division represents an extraordinary target to develop antitumor therapies. Indeed, a large number of clinically relevant anticancer drugs, such as taxanes and vinca alkaloids, target mitosis by stimulating or inhibiting microtubule (MT) polymerization. During the past decades anti-tubulin drugs have proven very effective against a wide range of tumors. However, collateral e...
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The development and survival of all organisms depends on equal partitioning of their genomes during cell division. Accurate chromosome segregation requires selective stabilization of kinetochore-microtubule attachments that come under tension due to opposing pulling forces exerted on sister kinetochores by dynamic microtubule tips. Here, we show that the XMAP215 family member, Stu2, makes a maj...
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Regulating the stability of microtubule (MT)-kinetochore attachments is fundamental to avoiding mitotic errors and ensuring proper chromosome segregation during cell division. Although biochemical factors involved in this process have been identified, their mechanics still need to be better understood. Here we introduce and simulate a mechanical model of MT-kinetochore interactions in which the...
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ژورنال
عنوان ژورنال: Oncoscience
سال: 2016
ISSN: 2331-4737
DOI: 10.18632/oncoscience.291